Analysis of Yes-Associated Protein-1 (YAP1) Target Gene Signature to Predict Progressive Breast Cancer.

For the TNBC subtype, the METABRIC dataset did not show any specific association with YAP1 expression, while subtype cohorts from TCGA showed a trend towards poorer outcomes ( Figure 2 D).

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Since YAP1 itself showed a strong trend towards worse survival outcomes, specifically in HER2-positive and TNBC subtypes, clustering analysis for shortlisted target genes was performed for these two subtypes to identify a progressive disease subset.

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