Covax-19/Spikogen® vaccine based on recombinant spike protein extracellular domain with Advax-CpG55.2 adjuvant provides single dose protection against SARS-CoV-2 infection in hamsters.

Vaccine · 2022 · PMC9013662 · PMID 35465982

Europe PMC DOI

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showed a trendno p-value reported

At week 2, the ECD (10 μg) construct showed a trend towards increased anti-spike total IgG compared to the equivalent dose of FL protein (10 μg) ( Fig. 1 C).

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may be significantno p-value reported

This titer of 1:160 may be significant as it is a key selection threshold for convalescent plasma to be considered therapeutic for COVID-19 patients [36] .

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did not reach statistical significanceno p-value reported

TNFα and IL-6 trended higher in the adjuvanted ECD compared to the FL group, but this difference did not reach statistical significance.

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