Among the remaining cytokines, IFN-λ1 showed a trend in elevation among COVID maternal samples, particularly among the Early COVID cohort (Supplementary Fig. 1A, B ).
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Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation.
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While this was significant for total cohort analysis, these values did not reach statistical significance in sub-analysis by gestational stage of SARS-CoV-2 infection (Fig. 4D ), likely due to the significant variability in cytokine values among Early and Late COVID sub-groups.