Primary tumour immune response and lymph node yields in colon cancer.

Conversely, when fixing the lower cut-off at ≤12 and changing the higher cut-off to ≥25, ≥30 and ≥35 a clear trend of increasing enrichment of the inflammation gene set was observed (Fig. 4a ).

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Of the common CRC driver mutations, APC ( P = 0.0188), TP53 ( P = 0.004), KRAS ( P = 0.003) and FBXW7 ( P = 0.024) were found more frequently mutated in low LN yield patients but did not reach statistical significance at multiple testing (Fig. 2a ).

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Strikingly, a highly significant enrichment for ‘hallmark’ gene sets associated with immune response in patients with high LN yield was found including INTERFERON_ALPHA_RESPONSE ( q < 0.005), INTERFERON_GAMMA_RESPONSE ( q < 0.005), ALLOGRAFT_REJECTION ( q < 0.005), and INFLAMMATORY_REPONSE ( q < 0.005) (Fig. 2b–e and Supplementary Table 3 ).

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