IL-27 Modulates the Cytokine Secretion in the T Cell-Osteoclast Crosstalk During HIV Infection.

We found a weak trend of an inverse correlation between the T score and the ability of T cells to secrete IFNγ in absence of IL-27 (R = −0.67, p = 0.011), ( Figure 3A ) .

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Total cholesterol and LDL and showed a positive trend with the levels of TNFα secretion by T cells (R = 0.60, p = 0.016 and R = 0.60, p = 0.012 respectively) but did not reach statistical significance ( Figure S3F ).

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T cells from PWH expressed lower basal levels of IL-10 and a trend was observed after stimulation of T cells cultured alone but did not reach statistical significance ( Figure 1D ).

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The secretion of IL-10 showed a trend of inhibition by IL-27, however did not reach statistical significance ( Figure 1H ).

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