A <i>dietary carbohydrate - gut Parasutterella - human fatty acid biosynthesis</i> metabolic axis in obesity and type 2 diabetes.

There were no significant associations in the zero part of the Hurdle model for all metabolites analyzed. Second, the pathway enrichment analysis of 76 metabolites that were successfully matched to terms of the SMPDB database resulted in two nominally significant pathways: fatty acid biosynthesis and α-linolenic acid metabolism ( P = 1.16e −2 , P = 4.62e −2 ) ( Figure 4 ).

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In the ATP cohort, a similar pattern was observed, whereby the difference between obese individuals with and without type 2 diabetes did not reach statistical significance, which might be due to the smaller number of subjects in ATP (n = 438, 5.2% diabetics) compared to FoCus (n = 1,544, 10.6% diabetics) ( Figure 1f ).

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