Variability in the type and layer distribution of cortical Aβ pathology in familial Alzheimer's disease.

In contrast, there was an observed trend for negative correlations between total cored plaque score and Aβ pathologies (subpial pathology, diffuse plaques, CWPs); this was particularly evident in the PSEN1 post‐codon 200 group, and slightly evident for diffuse plaques and CWPs in the APP group (Figure 3A–D ). 3.3.4 Differences across cortical layers As reported above, we did not find evidence of total Aβ pathology scores differing between the sub‐groups.

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When the three different plaque types were examined separately, there was a clear trend of a negative correlation between cored plaque score and Aβ load, both for the whole cohort and for all sub‐groups (Figure 4C ), and this was statistically significant for the whole cohort ( τ b = −0.37, p < 0.01 Kendall's tau‐b).

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While these relationships did not reach statistical significance, the negative correlations were seen consistently in the whole cohort, in all sub‐groups for cortical CAA, and in all but the small APP sub‐group for leptomeningeal CAA (see Figure 5B,C for the correlation coefficients).

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