Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration.

Transl Psychiatry · 2022 · PMC9061764 · PMID 35501309

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a negative trendno p-value reported

A negative trend for fatty acid (FA) 18:2 was observed post-ketamine, with a maximal decrease four hours post-infusion that did not return to baseline for 48 h.

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showed a trendno p-value reported

NAM levels were also increased in the whole blood of ketamine-treated mice and showed a trend towards increasing in (2 R ,6 R )-HNK-treated mice at several timepoints.

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a decreasing trendno p-value reported

SM C18:1 also had a decreasing trend post-ketamine.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.