Greater pre-flight PVS load was associated with more prior flight experience (r = 0.60–0.71), though these relationships did not reach statistical significance ( p > 0.05).
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Longitudinal MRI-visible perivascular space (PVS) changes with long-duration spaceflight.
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0.0500
0.0680
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showed a trendp = 0.068
There was no statistically significant pre-to post-flight difference by novice versus experienced status for the other PVS characteristics, though total PVS number showed a trend ( p = 0.068) similar to total PVS volume, in which the novice astronauts showed a mean pre- to post-flight increase in total PVS number, whereas the experienced astronauts showed a mean pre- to post-flight decrease in total PVS number.