Early administration of COVID-19 convalescent plasma with high titer antibody content by live viral neutralization assay is associated with modest clinical efficacy.

Patients also showed a trend in increasing hazard for days from diagnosis to transfusion, albeit non‐significant.

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Therefore, the reported ‘days from diagnosis’ is unlikely to precisely capture the timing of transfusion since initial infection or symptom onset, and may explain why this parameter, though trending toward favoring earlier treatment, did not reach statistical significance.

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