Adolescent Binge Alcohol Enhances Early Alzheimer's Disease Pathology in Adulthood Through Proinflammatory Neuroimmune Activation.

The AIE group showed a trend toward increased time sniffing the novel object ( p = 0.07, Figure 5D ) with no differences in time sniffing the familiar object ( Figure 5E ).

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Consistent with findings from the hippocampus, no main effect of sex on whole cortical p-tau-181 was found (F 1,17 = 0.007, p = 0.93) by western blot though a main effect of AIE was detected (F 1,17 = 5.93, p = 0.03) that did not reach statistical significance with post-hoc tests in either sex ( Supplementary Figure S2H ; Figure 3D ).

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