Glucose 6‐phosphatase ( G6pc ) mRNA levels in the liver were downregulated by the OD relative to NC in normoxia, but the downregulation in hypoxia did not reach statistical significance (Figure 5b ).
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Hypoxia ameliorates maternal diet-induced insulin resistance during pregnancy while having a detrimental effect on the placenta.
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In skeletal muscle upregulation of the Pfkl mRNA level by hypoxia was seen with both diets, but this failed to reach statistical significance (Figure 5c ). mRNA for another metabolic HIF target gene, the insulin sensitivity‐increasing insulin receptor substrate 2 ( Irs2 ), was downregulated by OD as compared with NC in the liver under hypoxic conditions, whereas the downregulation did not reach statistical significance in normoxia (Figure 5c ).