nominally significantp -value<0.05
For 18S_1 , 18S_2 , and 28S targets, we found few CpG sites showing nominally significant association ( p -value<0.05) of DNAm with age.
For 18S_1 , 18S_2 , and 28S targets, we found few CpG sites showing nominally significant association ( p -value<0.05) of DNAm with age.
The EpiTYPER analysis showed a trend toward rDNA hypermethylation in DS compared to CTRL that reached statistical significance (q-value <0.05) for some CpG units, thus confirming the results generated by targeted-bisulfite sequencing ( Supplementary Figure S4 ).