Selective Inhibition of PDE4B Reduces Methamphetamine Reinforcement in Two C57BL/6 Substrains.

This comparison yielded a near-significant strain effect (F (1,44) = 4.01, p = 0.05) with B6J mice directing a greater proportion of their total response towards the active hole ( Figure 2 D), but no sex difference was detected for this variable (sex effect and interactions, p ’s > 0.14).

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Although B6NJ females tended to respond more in the inactive hole than males at higher MA concentrations, no sex difference was apparent in this substrain ( Figure 3 B, right) (sex×concentration ANOVA, all p ’s > 0.12).

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