Systemic DNA and RNA damage from oxidation after serotonergic treatment of unipolar depression.

Transl Psychiatry · 2022 · PMC9110351 · PMID 35577781

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

a borderline significant trendp = 0.054so close (0.05 < p ≤ 0.1)

We found a borderline significant trend towards an association between the 8-oxodG pre-post intervention change and categorical response status (F(2,73) = 2.91, p = 0.054), with all remitters showing a reduction in 8-oxodG excretion as compared to the non-responders and intermediate responders.

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showed a trendno p-value reported

The changes were not correlated with overall symptom reduction but showed a trend towards an association to remission status.

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highly significantno p-value reported

We found a highly significant reduction in the excretion of both nucleic acid oxidation markers at week 8 compared to baseline (8-oxodG: −0.43 [95% CI −0.55 to −0.32] nmol/mmol, t = −7.70, p < 0.0001. 8-oxoGuo: −0.16 [95% CI −0.24 to −0.07] nmol/mmol, t = −3.68, p = 0.0004) (Fig. 1 ).

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