Single Nucleotide Polymorphism Effects on Lamb Fecal Egg Count Estimated Breeding Values in Progeny-Tested Katahdin Sires.

3 Results 3.1 Evaluation of Candidate Regions None of the SNP within the five candidate regions had even a nominally significant association with FEC EBV ( p > 0.10). 3.2 Bin-Based Genome-Wide Association Study for Non-Candidate Regions 3.2.1 Tests of Significance For WFEC, four bins on chromosome 5 and two bins on chromosome 16 achieved BB genome-wide significance, and an additional 59 bins contained SNP with BB chromosome-wide significance.

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In addition, RHM provided opportunity to account for apparent clumping of marginally significant individual SNP on chromosome 5, thereby detecting a significant influence on FEC for a candidate region that had not been previously identified but included potentially important functional and regulatory genes.

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Results of single-marker regression analysis do not, however, explicitly consider clumping of significant, or near-significant, SNP in specific regions of the genome.

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