Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.

Tissue viral loads were assessed on day 5 postinfection, with pixatimod-treated animals showing a significant 3.1 log 10 -fold reduction in viral titers in nasal turbinates ( p = 0.037, Kolmogorov–Smirnov test, nonparametric data distribution) and a 4.6 log 10 -fold reduction in viral titers in the brain, which approached significance ( p = 0.0588, t test, parametric data distribution).

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38 Why pixatimod should have such a significant effect on viral titers in the nasal turbinates (and approaching significance in the brain), but not lungs in the K18-hACE2 model, is unclear but may reflect very high lung (supraphysiological) K18-driven hACE2 receptor expression in the lungs in this model 44 and/or pixatimod pharmacokinetics. 40 Nevertheless the results are encouraging, especially as recent data suggest th

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