Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs.

Geroscience · 2023 · PMC9137444 · PMID 35622271

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.6000

boldest claim

The sentences

showed a trendP = 0.08so close (0.05 < p ≤ 0.1)

However, IL37 HAP1 showed a trend toward an inverse association with factor 3, “the blood pressure and adiposity” factor ( P = 0.08; Fig. 5A ), suggesting that individuals with 1 or 2 copies of this haplotype’s minor alleles may be better protected against increased diastolic blood pressure and/or adiposity.

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did not reach statistical significancep = 0.60not close (p > 0.1)

The average concentration of IL-37 protein was higher in individuals with 2 minor allele copies of IL37 HAP2; however, this did not reach statistical significance due to the low number of subjects with this genotype (only 3) (ANOVA main effect: p = 0.60; Fig. 4B ).

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