Consistent with previously published data, CaMKK2 LKO mice showed a trend toward decreased blood glucose when subjected to a pyruvate tolerance test (PTT) ( Fig.
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Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism.
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Due largely to the lower number of altered genes, GSEA failed to reach statistical significance, but we noted a trend toward negative enrichment for genes associated with oxidative phosphorylation in the AAV9- CaMKK2 treated group, further supporting the observation that loss of hepatic CaMKK2 appears to sponsor an increase in lipid metabolism, consistent with our previous report [ 15 ] ( Fig.