A Drug Combination Rescues Frataxin-Dependent Neural and Cardiac Pathophysiology in FA Models.

The relative beam walk performance determined by average time to cross a beam during the test period compared to the initial pretreatment average time to cross the beam (seconds) showed a trend of improvement after 3 months of treatment and at increased dosage, although no significant differences were witnessed between FA (vehicle)- and DMF–Resv-treated mice ( Figure 5B ).

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The results showed that in these short-term studies, there was a trend to increased levels of FXN mRNA expression ( Figure 4A ) and mt/nDNA ratio ( Figure 4B ) in the combined DMF–Resv treatment, although levels did not reach statistical significance.

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