Treatment with IFB-088 Improves Neuropathy in CMT1A and CMT1B Mice.

3a, b ) and BiP protein (which however did not reach statistical significance) (Fig. 3d, f ), whereas the levels of Xbp1s were unchanged (Fig. 3c ).

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However, when divided by gender, C3-PMP22 male mice showed a trend towards improvement at 0.5 mg/kg b.i.d. which became significant for the 1-mg/kg b.i.d. of IFB-088 (Fig. 5g ).

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