In vivo experiments of AAV showed that high expression of CCL19 and CCL21 inhibits the growth of HCC by influencing the infiltration of CD3 + T cells and CD20+ B cells in the subcutaneous xenograft model, while there was a slight significance in the DEN/CCl4-induced tumor models when compared with tumor sizes in two groups.
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Spatial maps of hepatocellular carcinoma transcriptomes reveal spatial expression patterns in tumor immune microenvironment.
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Results showed that overexpressing combined Ccl19 / Ccl21a can remarkably retard tumor growth and decrease tumor vitality of hepa1-6 cells, while overexpressing Ccl19 or Ccl21a alone showed a slightly significant difference of tumor growth compared to the control group ( Figure S5 B-D), indicating that overexpressing combined Ccl19 and Ccl21a elicited a synergistic effect in inhibiting the tumor growth.