Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.

Although signaling trajectories trended in the same direction among most patients ( Figure S3 C), we did not observe a clear trend toward healthy individuals ( Figure S3 D), likely explained by the expression variability and difficulty of measuring signaling molecules in rare populations in healthy individuals, e.g., activated CD8 T cells ( Figure 3 E).

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We also observed an overall trend of negative correlations between median signaling in CD45 + cells and hospital length of stay as a continuous variable, though these did not reach statistical significance (FDR > 0.1, Figure S2 D).

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