Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response.

Interestingly, we observed that 4-hour plasma levels for both canine KC-like and IL-8 chemokines ( figure 2D ) were higher in responders compared with non-responders with the differences for KC-like reaching statistical significance (p=0.046), while for IL-8, the differences approached but did not reach statistical significance (p=0.09).

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45 Concentrations of IL-7, a critical cytokine in the homeostatic expansion of T cells, 43 46 showed a trend to be higher in OSA versus melanoma, although remained highly variable among patients.

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