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A Nine-Strain Bacterial Consortium Improves Portal Hypertension and Insulin Signaling and Delays NAFLD Progression In Vivo.

Biomedicines · 2022 · PMC9175091 · PMID 35625927

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The Inverse Simpson diversity index revealed that, although not reaching the microbial diversity levels of the control diet (CD) group, diversity improved over vehicle (HFGFD-VEH) in both treatment groups; this was nearly statistically significant in the bacterial consortium (HFGFD-CON) treatment group ( Figure 4 ).

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The Metabolic Profile Improved in the Treatment Groups Both microbiota-based treatments displayed an important reduction in fasting blood glucose and insulin levels, and HOMA-IR index with respect to the HFGFD-VEH group, although these differences did not reach statistical significance ( Table 1 and Figure S1B,C ).

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