Stem Cell-Based Regenerative Therapy and Derived Products in COPD: A Systematic Review and Meta-Analysis.

Cells · 2022 · PMC9180461 · PMID 35681492

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0560

boldest claim

The sentences

tendency towards significancep = 0.056so close (0.05 < p ≤ 0.1)

Active treatments elicited a strong tendency towards significance in FEV 1 improvement (+71 mL 95% CI -2–145; p = 0.056) and significantly increased 6MWT (52 m 95% CI 18–87; p < 0.05) vs. baseline or control.

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a trend towards significanceno p-value reported

Discussion The main findings of this study indicated that treatment with stem cell-based regenerative therapies and derived products significantly improved exercise capacity in COPD patients and produced a trend towards significance for an improvement in FEV 1 , but no other lung function parameters showed a significant difference compared to baseline or CTL.

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showed a trendno p-value reported

In the present analysis, although data on FEV 1 failed to meet the significance threshold of p < 0.05 and rather showed a trend towards significance, this may be an indication that the study was not able to demonstrate a difference, perhaps due to insufficient sample sizes [ 86 ].

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