Reduced expression of mitochondrial fumarate hydratase in progressive multiple sclerosis contributes to impaired in vitro mesenchymal stromal cell-mediated neuroprotection.

However, a statistically significant effect was not observed when confounding effects of age were taken into account; there was a strong trend towards an increase in FH activity with age ( p = 0.059) although the trend was less marked in MS-MSC ( Figure 2(b) ).

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Although reduced FH activity was observed in MS-MSC, this effect did not reach statistical significance after adjustment for differences in age between the cohorts and furthermore, no difference was seen when FH activity was assessed in mitochondrial preparations from MSC isolated from control subjects and people with progressive MS.

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