Absence of P2Y₂ Receptor Does Not Prevent Bone Destruction in a Murine Model of Muscle Paralysis-Induced Bone Loss.

Compared to the saline injected mice, the trabecular BV/TV was reduced by 38.01% ± 6.1 in BTX WT ( P = 0.0029) versus 37.92% ± 4.7 in BTX KO ( P = 0.0023); structure model index (SMI, a widely used measure for rods and plates in trabecular bone), was increased by 25.64% ± 3.3 in BTX WT ( P = 0.0006) versus 19.32% ± 5.9 in BTX KO ( P = 0.0394); thickness was reduced by 21.86% ± 3.7 in BTX WT ( P = 0.0003) versus 27.12% ± 9.4 in BTX KO ( P = 0.0080); and, degree of anisotropy (DA, a measure of trabecular orientation) were significantly reduced by 13.52% ± 2.2 in BTX WT ( P = 0.0009) and approaching significance in BTX KO (8.64% ± 2.3, P = 0.0546).

also in 2,640 other papers

However, compared to the baseline a body-weight reduction after 17- (6.06% ± 2.1, P = 0.0441), 18- (7.69% ± 1.9, P = 0.0052) and 19 weeks (7.08% ± 1.6, P = 0.0123) was seen only in BTX KO mice; while, the reduction did not reach statistical significance in BTX WT mice.

also in 111,027 other papers