Negative interaction between nitrates and remote ischemic preconditioning in patients undergoing cardiac surgery: the ERIC-GTN and ERICCA studies.

Basic Res Cardiol · 2022 · PMC9213287 · PMID 35727392

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0.1350

closest p · 2.7× alpha

0.1350

boldest claim

The sentences

did not reach statistical significancep = 0.135not close (p > 0.1)

However, when considering IV GTN only irrespective of use of long-term use of oral nitrates, the interaction with RIPC was weaker, and did not reach statistical significance ( p = 0.135, Supplementary Table 4 and Fig. 2).

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showed a trendno p-value reported

Prior evidence that suggest a possible protective effect of GTN include a 2017 meta-analysis of secondary data from five small trials (total 180 patients) in patients undergoing cardiac surgery which showed a trend towards less PMI but it did not reach statistical significance [ 18 ].

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