Subventricular zone adult mouse neural stem cells require insulin receptor for self-renewal.

Although there was a trend toward decreased body weight in ΔNSC-IRKO versus control mice, the difference did not reach statistical significance (see Figure S5 D).

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In the median eminence, both the β2-tanycytes and rapidly proliferating CldU + transit-amplifying cells showed a trend toward a decrease in number (see Figures S6 A–S6C).

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