AspRS protein levels were lowered by 50% in the CX and CB of Dars1 M256L/− mice, however, AspRS protein reduction did not reach statistical significance in the BS and BG (Fig. 5 B and C).
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Developmental delay and late onset HBSL pathology in hypomorphic Dars1<sup>M256L</sup> mice.
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Taken together, there is a clear trend towards reduction of myelin markers in the CB and BS of Dars1 M256L/− mice, which may reflect potential myelination or oligodendrocyte defects in hindbrain areas of Dars1 M256L/− mice.