Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity.

In cixutumumab-treated mice, basal Akt in liver ( Figure 6(a )) and skeletal muscle ( Figure 6 ) d)) tended to be lower than isotype control-treated mice but this did not reach statistical significance.

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In cixutumumab-treated mice, phosphorylation of Akt ( Figure 6(b )) showed a strong trend towards an increase in liver, while skeletal muscle showed no difference ( Figure 6(e )).

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