Myotonic dystrophy RNA toxicity alters morphology, adhesion and migration of mouse and human astrocytes.

Overall, most exons studied were significantly misspliced in adult DM1 brain samples, compared to non-DM controls: eight out of eleven exons were affected in frontal cortex ( ITGB4 exon 35 and MPDZ exon 28 showed a clear trend but did not reach statistical significance) (Fig. 9d ), whereas all exons studied were misspliced in the hippocampus of DM1 patients (Fig. 9e ).

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