(2018) explored age-related differences in amygdala response and found a trend wise negative linear association between amygdala activity and face trustworthiness in young adults, but older adults showed a trend wise positive quadratic relationship (i.e., high and low compared to moderate face trustworthiness was associated with greater amygdala activity).
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Age-Related Differences in Amygdala Activation Associated With Face Trustworthiness but No Evidence of Oxytocin Modulation.
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placebo administration as between-subject factor a sample size of 64 participants per treatment group is necessary to obtain sufficient power (80%) to detect a moderate effect of oxytocin on social cognition (see Supplementary Material for details regarding the interaction we observed between treatment group and face trustworthiness level, which were not statistical significant as per our alpha level cut off, but approached significance).