11β-Hydroxysteroid Dehydrogenase Type 1 within Osteoclasts Mediates the Bone Protective Properties of Therapeutic Corticosteroids in Chronic Inflammation.

Int J Mol Sci · 2022 · PMC9266304 · PMID 35806338

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showed a trendno p-value reported

In contrast, osteoclast numbers showed a trend towards a partial suppression in TNF-tg 11βKO animals receiving corticosterone (62%; NS).

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approached significanceno p-value reported

Micro-CT analysis of the trabecular bone revealed that TNF-tg 11βflx/tw2cre retained a corticosteroid mediated protection from inflammatory trabecular bone loss in the tibia relative to vehicle treated controls, having greater BV/TV (51% p = 0.059) and trabecular number (39%; p = 0.061) that approached significance and closely mirrored the responses seen in TNF-tg animals ( Figure 4 B–E).

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