Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis.

In contrast, after 2 weeks of remyelination in the presence of LKE there were significant increases in both MBP and PLP in both CC and CX, as compared to the CPZ group. While staining intensities for MBP and PLP were always greater in the CPZ/LKE groups than the CPZ/CTL groups, those differences did not reach statistical significance except for PLP staining in the CC.

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Treatment with LKE reduced clinical scores, glial inflammation and axonal damage, and showed a trend towards increasing myelin thickness ( Dupree et al., 2015 ).

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