17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes.

Mol Neurodegener · 2022 · PMC9284779 · PMID 35841044

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

highly significantp = 1.12 × 10 –9actually significant

nominally significantp < 0.002actually significant

Block H1.2 was highly significant in Stage 2 data ( p = 1.12 × 10 –9 ), while both blocks H1.1 and H1.3 were nominally significant ( p < 0.002 and p < 0.0003, respectively).

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did not reach statistical significanceno p-value reported

The Stage 1 top SNP, rs41543512, was associated with an OR of 1.21 (95% CI 1.10–1.32, p < 0.001; Figure S 1 I, Table S 1 ), but did not reach statistical significance in Stage 2 data or meta-analysis (Table S 1 ).

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