L-carnitine supplementation for muscle weakness and fatigue in children with neurofibromatosis type 1: A Phase 2a clinical trial.

Furthermore, handwriting speed was increased by 15% on average; however, due to the considerable variability in participant performance, this failed to reach statistical significance (95% CI −7.38 to 20.24; p = 0.28) (Figure 1c ).

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Comparison of PedsQLTM scores between baseline and 12‐weeks posttreatment showed a trend toward improvement on the physical health summary domain of the generic module (median 46.9, interquartile range [IQR] 42.2–60.9 to median 71.9, IQR 51.6–87.5) (Figure 3 ; Supporting Table 5 ).

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