Zfhx3 modulates retinal sensitivity and circadian responses to light.

These differences reached borderline significance ( P = .0602) while a curve comparison F ‐test indicated a significant genotype effect in the amplitude of the maximum achievable response ( P = .0006).

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These differences were consistently observed in dark‐adapted animals and show a strong trend indicating that Zfhx3 Sci/+ mice can exhibit an exaggerated cortical response to a bright flash stimulus when compared to controls animals. 3.6 Zfhx3 Sci/+ retina shows increased sensitivity of light responses in multiple electrode array (MEA) recordings Given the evidence for ZFHX3 expression within ipRGCs and altered light entrainment and enhanced pupillary light responses in Zfhx3 Sci/+ mice, behaviors both driven by ipRGCs, we next used multiple electrode array (MEA) recordings of ex vivo retinal explants to assess light responses in Zfhx3 Sci/+ mice.

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