The kinetic of CBT adaptation to exercise (first minutes of the 6MWT) showed a trend towards higher values of τCBT in PwMS (101 ± 49 s) than in HS (71 ± 14 s; p=0.07), which was however above the limit of statistical significance.
Although the internal load, the core heat accumulation and dissipation, and the perceptual load were similar during the 6MWT between our experimental groups, the total mechanic work produced by the PwMS group was dramatically reduced compared to that of the MS group: this is indirectly demonstrated by the highly significant difference in the distances covered during the test, which about halved in the PwMS group.
Finally, a clear trend towards a greater perceived exertion is apparent in the PwMS group ( Figure 3 ).