The effect of aspartame and sucralose intake on body weight measures and blood metabolites: role of their form (solid and/or liquid) of ingestion.

Fasting plasma insulin levels failed to reach significance between the groups ( P = 0·125), whereas HOMA-IR was significantly different between groups ( P = 0·04) and strongly related to the amount of ingested aspartame ( r = 0·518, P = 0·006), and thus insulin sensitivity was inversely related to aspartame intake.

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However, the modest increase in plasma glucose of the sucralose groups did not reach statistical significance.

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Moreover, all measures of energy balance were similar between the groups, with energy intake, expenditure and efficiency failed to reach statistical significance ( Table 3 ).

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