Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.

Linear regression analysis of AUC inf,u vs renal function showed a clear trend of increasing AUC inf,u with decreasing eGFR (Figure 4E ).

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Linear regression analysis of AUC inf vs renal function for the 3 metabolites showed a trend of increasing AUC inf with decreasing eGFR (Figure 4B‐D ).

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