DSCAM-AS1 Long Non-Coding RNA Exerts Oncogenic Functions in Endometrial Adenocarcinoma via Activation of a Tumor-Promoting Transcriptome Profile.

Although the knockdown in RL95-2 cells was unsatisfactory, when we examined the clinical relevance of these eight genes in endometrial cancer in terms of association with patients’ survival using the RNA-seq data from 543 EC patients [ 28 ] provided by the database of the Kaplan-Meier Plotter website https://kmplot.com , we observed that the upregulated genes CHPF, PAQR8 and SAR1B were associated with longer overall survival (OS), whereas the downregulated genes PTK2, THSD4 and LNPEP were significantly associated with a shorter OS (PTK2) or showed a trend towards adverse OS in this cancer entity ( Figure S2 ).

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Computing overlaps with the MSigDB database (gene set collections H and C2 to C6) resulted in identification of several highly significant gene set overlaps, including tumor-promoting gene sets of breast cancer cells or cholangiocarcinoma ( Table S2 ).

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With regard to canonical pathways using all corresponding databases, only a weakly significant overlap (5 of 30 genes) with REACTOME TRAF6 MEDIATED IRF7 ACTIVATION [ 30 ] was identified ( Table 1 a).

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