A Single Domain Shark Antibody Targeting the Transferrin Receptor 1 Delivers a TrkB Agonist Antibody to the Brain and Provides Full Neuroprotection in a Mouse Model of Parkinson's Disease.

Pharmaceutics · 2022 · PMC9318160 · PMID 35890231

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

In this study the unmodified TrkB agonist antibody showed a trend towards limited neuroprotection in the SNc, although it did not reach statistical significance, despite a 3-fold greater potency relative to TXB4-TrkB.

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