Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity.

Nat Commun · 2022 · PMC9329324 · PMID 35896531

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.2200

boldest claim

The sentences

nominally significantP = 9.65 × 10 −4actually significant

Heterozygous carriers of INHBE pLOF variants (1 in 587 individuals, combined frequency of 0.08%) had a favorable metabolic profile consisting of nominally significant associations with lower triglycerides ( P = 9.65 × 10 −4 , Beta = −0.13 SD), higher HDL cholesterol ( P = 0.01, Beta = 0.10 SD), decreased alanine aminotransferase ( P = 0.04, Beta = −0.08 SD) and lower fasting glucose ( P = 0.03, Beta = −0.17 SD).

also in 7,732 other papers

did not reach statistical significanceP = 0.22not close (p > 0.1)

There were fewer cases of T2D among INHBE pLOF carriers in a larger meta-analysis of ~900,000 people but this also did not reach statistical significance (rs150777893 variant; P = 0.22, OR = 0.65, 95% CI 0.33 to 1.29) 31 .

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.