Activation of NLRP3 Is Required for a Functional and Beneficial Microglia Response after Brain Trauma.

Pharmaceutics · 2022 · PMC9332196 · PMID 35893807

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.0590

boldest claim

The sentences

near-significantp = 0.057so close (0.05 < p ≤ 0.1)

Kruskal–Wallis showed an effect of lesion in WT animals ( p = 0.004) and NLRP3 KO ( p = 0.000), with a near-significant difference ( p = 0.057) on the ipsilateral sides of WT and KO mice ( Figure 2 a, left).

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almost significantp = 0.058so close (0.05 < p ≤ 0.1)

The Clec7a microglial marker presented a similar pattern and Kruskal–Wallis test showed a significant effect of lesion in WT ( p = 0.007) and KO (0.003) mice; Mann–Whitney U-test confirmed a significant increase in the ipsilateral side of WT animals ( p = 0.002) and an almost significant difference in the contralateral side with the WT naïve group ( p = 0.058).

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a strong trendp = 0.059so close (0.05 < p ≤ 0.1)

Gfap mRNA levels were analyzed by non-parametric test and Kruskal–Wallis showed a significant effect of lesion in WT ( p = 0.013) and KO ( p = 0.000), with a strong trend towards higher basal levels in KO than in WT ( p = 0.059).

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