Acute myeloid leukemia: negative prognostic impact of early blast persistence can be in part overcome by a later remission prior to post-induction therapy.

Haematologica · 2022 · PMC9335105 · PMID 34758607

Europe PMC DOI

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0.0580

closest p · 1.2× alpha

0.0690

boldest claim

The sentences

a clear trendP =0.058so close (0.05 < p ≤ 0.1)

15%, P =0.037) ( Figure 5A ), and there was a clear trend towards inferior survival in the multivariate model (HR=1.6, 95% CI: 1.0-2.7, P =0.058), suggesting an adverse prognostic impact of early PR on RFS which was most likely compensated by subsequent salvage therapy with regard to OS.

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a strong trendP =0.069so close (0.05 < p ≤ 0.1)

Moreover, in patients with early blast persistence, there was a strong trend towards a higher risk of non-relapse mortality, even in the presence of other risk factors (CS-HR=1.4, P =0.069) ( Table 2 ).

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