Impact of Replacement of Individual Dietary SFAs on Circulating Lipids and Other Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials in Humans.

Adv Nutr · 2022 · PMC9340975 · PMID 34849532

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showed a trendno p-value reported

LDL cholesterol:HDL cholesterol ratio The replacement of dietary palmitic acid with a mixture of UFAs and its impact on the LDL cholesterol:HDL cholesterol ratio was investigated in 6 RCTs and showed a trend for a beneficial effect (i.e., decrease), although the quantitative synthesis did not reach statistical significance (WMD: −0.25; 95% CI: −0.60, 0.09; I 2 = 17.6%, n = 6 RCTs) ( Supplemental Figure 5 ).

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did not reach statistical significanceno p-value reported

TC:HDL cholesterol ratio Replacing dietary palmitic acid with oleic acid or a mixture of UFAs led to a trend for a decrease in the TC:HDL cholesterol ratio, but the quantitative syntheses based on 3 and 4 RCTs, respectively, did not reach statistical significance ( Supplemental Figure 4 ).

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