Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 correlate with tuft cell abundance and marker expression in silico.

Pseudo-bulked expression from 11q23.1 nominally significant trans-eQTL targets, present in the scRNAseq dataset (p < 0.01, n = 273), Fig. 2 a, was then subject to WGCNA 20 .

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To first test gene–gene relatedness within cluster 11, we performed WGCNA on the relative, pseudo-bulked expression of the top 5000 most variable genes within this cluster, identifying a total of 20 modules, 7 of which exhibited correlations with sample covariates that approached significance (FDR < 0.1), Fig. 4 b.

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