Postnatal Dexamethasone Therapy Impairs Brown Adipose Tissue Thermogenesis and Autophagy Flux in Neonatal Rat Pups.

First, we examined mitochondrial fusion proteins, and found that after Dex treatment, the level of mitofusin 2 (MFN2) was significantly increased in the tissue lysate; optic atrophy 1 (OPA1) protein also showed a trend of increase; while the level of MFN1 protein was similar (Figure 3 C).

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For mitochondrial fission proteins, the level of dynamin-related protein 1 (DRP1) showed a decreasing trend in Dex group but did not reach statistical significance (Figure 3 D).

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